Microfluidic devices to enrich and isolate circulating tumor cells
نویسندگان
چکیده
منابع مشابه
Self-propelled microrockets to capture and isolate circulating tumor cells.
The first report of circulating tumor cells (CTCs) can be traced back to 1869 when Thomas Ashworth, an Australian physician, observed tumor cells in the blood of a patient who succumbed to advanced metastatic cancer. Since then cancer research has proved the critical roles played by CTC in the metastatic spread of carcinomas. In addition, CTCs contain key information of how tumor genotypes evol...
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Metastatic cancer can recur months or even years after apparently successful treatment of the primary tumor. While the exact mechanisms leading to cancer recurrence remain poorly understood, failure to completely eliminate dormant micrometastases and solitary metastatic cells is believed to be a major contributor. Thus, while not of initial clinical concern, metastatic dormancy is still a signi...
متن کاملMetastasis and Circulating Tumor Cells
Cancer is a prominent cause of death worldwide. In most cases, it is not the primary tumor which causes death, but the metastases. Metastatic tumors are spread over the entire human body and are more difficult to remove or treat than the primary tumor. In a patient with metastatic disease, circulating tumor cells (CTCs) can be found in venous blood. These circulating tumor cells are part of the...
متن کاملCirculating Tumor Cells and Circulating Tumor DNA: Challenges and Opportunities on the Path to Clinical Utility.
Recent technological advances have enabled the detection and detailed characterization of circulating tumor cells (CTC) and circulating tumor DNA (ctDNA) in blood samples from patients with cancer. Often referred to as a "liquid biopsy," CTCs and ctDNA are expected to provide real-time monitoring of tumor evolution and therapeutic efficacy, with the potential for improved cancer diagnosis and t...
متن کاملCirculating tumor cells.
A typical cancerous tumor contains millions or even billions of cells harboring genetic mutations driving them to grow, divide, and invade the local tissue in which they’re embedded. However, as the cells proliferate, they don’t all stay in the neighborhood. Some cells slough off the edges of a tumor and are swept away by the bloodstream or lymphatic system. These so-called circulating tumor ce...
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ژورنال
عنوان ژورنال: Lab on a Chip
سال: 2015
ISSN: 1473-0197,1473-0189
DOI: 10.1039/c5lc00947b